Interleukin 12: Newest Member of the Antiangiogenesis Club
نویسندگان
چکیده
منابع مشابه
Direct in vitro evidence and in vivo analysis of the antiangiogenesis effects of interleukin 12.
As an antitumor agent, interleukin-12 (IL-12) has been revealed to be a key regulator of the immune response, particularly that involving CTL and natural killer (NK) cells. We report herein the antiangiogenesis effect of IL-12 on human as well as murine tumors in NK-depleted severe-combined immunodeficient mice using fibroblasts genetically engineered to secrete this cytokine. Although the in v...
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ژورنال
عنوان ژورنال: JNCI Journal of the National Cancer Institute
سال: 1995
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/87.8.557